Istituto Zooprofilattico Sperimentale delle Venezie
Italian health authority and research organization for animal health and food safety
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De Benedictis Paola

Paola De Benedictis | Istituto Zooprofilattico Sperimentale delle Venezie Role Veterinarian
Department SCS5 – Research and innovation
National reference centre / FAO reference centre for rabies
Phone +39 049 8084385

Professional profile

Paola De Benedictis is currently working at the Laboratory for viral zoonoses and emerging and re-emerging pathogens at the IZSVe. Education: degree in Veterinary medicine (University of Bologna, 2002), postgraduate specialization in Animal health, breeding and livestock production (University of Teramo, 2006), PhD on Innovative technologies for the detection and control of rabies (University of Padua, 2012).

She is a virologist experienced in research on viral zoonoses. Since 2005 she has been involved in particular in rabies diagnosis in suspected animals and human beings, and has been actively engaged in the assessment of the response to rabies vaccination and of rabies neutralizing antibody titer test. Over the years her working group has been acknowledged on a national and international level thanks to the objectives achieved through the development of new diagnostic tools, the support to developing countries and the development of new generation immunotherapeutics for rabies prevention in humans.

Paola De Benedictis is the responsible of both the FAO-UN and the national reference centers for rabies at the IZSVe and is member of the OIE Collaborating Center for Diseases at the human-animal interface, where she mainly investigates the mechanisms which favour inter-species transmission of viral pathogens and in the development of innovative therapies in humans.

She is project/work package leader and/or collaborator in national and international research projects embracing topics such as the pathogenesis, diagnosis, molecular epidemiology and control of viral zoonoses, with particular reference to rabies. In 2015 she joined the Partners for Rabies Prevention group and together with the European reference centers she is committed to supporting international networks involved in topics of major epidemiological relevance, i.e. the EU Reference Center (ANSES, France) and OIE/WHO agencies.


  • Eggerbauer, E., De Benedictis, P., Hoffmann, B., Mettenleiter, T.C., Schlottau, K., Ngoepe, E.C., Sabeta, C.T., Freuling, C.M., & Muller, T. (2016). Evaluation of Six Commercially Available Rapid Immunochromatographic Tests for the Diagnosis of Rabies in Brain Material.10, e0004776. PLoS neglected tropical diseases, Jun 23 doi:10.1371/journal.pntd.0004776 [doi]
  • Rota Nodari, E., Alonso, S., Mancin, M., De Nardi, M., Hudson-Cooke, S., Veggiato, C., Cattoli, G., & De Benedictis, P. (2016). Rabies Vaccination: Higher Failure Rates in Imported Dogs than in those Vaccinated in Italy. Zoonoses and public health, Blackwell Verlag GmbHMay 6 doi:10.1111/zph.12268 [doi]
  • Aiello, R., Zecchin, B., Caenazzo, S.T., Cattoli, G., & Benedictis, P. (2016). Disinfection protocols for necropsy equipment in rabies laboratories: safety of personnel and diagnostic outcome. Journal of virological methods. Published by Elsevier B.VApr 15 doi:S0166-0934(15)30123-3 [pii]
  • De Benedictis, P., Minola, A., Rota Nodari, E., Aiello, R., Zecchin, B., Salomoni, A., Foglierini, M., Agatic, G., Vanzetta, F., Lavenir, R., Lepelletier, A., Bentley, E., Weiss, R., Cattoli, G., Capua, I., Sallusto, F., Wright, E., Lanzavecchia, A., Bourhy, H., & Corti, D. (2016). Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis. EMBO molecular medicine, Humabs BioMed SA Published under the terms of the CC BY 4.0 licenseMar 18 doi:e201505986 [pii]
  • Lelli, D., Beato, M.S., Cavicchio, L., Lavazza, A., Chiapponi, C., Leopardi, S., Baioni, L., De Benedictis, P., & Moreno, A. (2016). First identification of mammalian orthoreovirus type 3 in diarrheic pigs in Europe.13, 139-016-0593-4. Virology journal, Aug 12 doi:10.1186/s12985-016-0593-4 [doi]
  • Leopardi, S., Oluwayelu, D., Meseko, C., Marciano, S., Tassoni, L., Bakarey, S., Monne, I., Cattoli, G., & De Benedictis, P. (2016). The close genetic relationship of lineage D Betacoronavirus from Nigerian and Kenyan straw-colored fruit bats (Eidolon helvum) is consistent with the existence of a single epidemiological unit across sub-Saharan Africa. Virus genes, Apr 8 doi:10.1007/s11262-016-1331-0 [doi]
  • De Benedictis P, Marciano S, Scaravelli D, Priori P, Zecchin B, Capua I, Monne I, Cattoli G. (2014). Alpha and lineage C betaCoV infections in Italian bats. Virus Genes. Apr;48(2):366-71. doi: 10.1007/s11262-013-1008-x. Epub 2013 Nov 16. PubMed PMID: 24242847.
  • Fusaro A, Monne I, Salomoni A, Angot A, Trolese M, Ferrè N, Mutinelli F, Holmes EC, Capua I, Lemey P, Cattoli G, De Benedictis P (2013). The introduction of fox rabies into Italy (2008-2011) was due to two viral genetic groups with distinct phylogeographic patterns. Infect Genet Evol. 2013 Jul;17:202-9. doi: 10.1016/j.meegid.2013.03.051. Epub 2013 Apr 19. PubMed PMID: 23603764.
  • De Benedictis P, Perboni G, Gentili C, Gaetti L, Zaffanella F, Mutinelli F, Capua I, Cattoli G. (2012). Fatal case of human rabies imported to Italy from India highlights the importance of adequate post-exposure prophylaxis, October 2011. Euro Surveill. 2012 May 10;17(19). pii: 20168. PubMed PMID: 22607965.
  • De Benedictis P, De Battisti C, Dacheux L, Marciano S, Ormelli S, Salomoni A, Caenazzo ST, Lepelletier A, Bourhy H, Capua I, Cattoli G. (2011) Lyssavirus detection and typing using pyrosequencing. J Clin Microbiol. 2011 May;49(5):1932-8. doi: 10.1128/JCM.02015-10. Epub 2011 Mar 9. PubMed PMID: 21389152; PubMed Central PMCID: PMC3122702.
  • De Benedictis P, Schultz-Cherry S, Burnham A, Cattoli G. (2011). Astrovirus infections in humans and animals – molecular biology, genetic diversity, and interspecies transmissions. Infect Genet Evol. 2011 Oct;11(7):1529-44. doi: 10.1016/j.meegid.2011.07.024. Epub 2011 Aug 5. Review. PubMed PMID: 21843659.

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Istituto Zooprofilattico Sperimentale delle Venezie
Viale dell'Università 10, 35020 Legnaro (PD)
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